Statin Statinsdrugs are used to lower cholesterol in the body, actually body needs somecholesterol to work. If cholesterol level increases in blood it stick to thewalls of arteries and makes narrow or even block them.
Bydiet and exercise if cholesterol levelsdid not reduce, then it will be necessaryto take medicine. Often, this medicine is a statin. Statins they lower LDL(bad)cholesterol levels and raise HDL (good) cholesterol levels. This willmake slow the formation of plaques in arteries.Statinsare safe for most people. But these medicines are not recommended for pregnantpatients and patients with chronic liver disease.
They can also cause seriousmuscle problems. Some statins interact adversely with other drugs. This may causefewer side effects.Statins – the good,the bad and the controversyStatins – the goodIf cholesterol levels are high in the body it causes coronaryartery disease due to this fatty deposits build up in the walls of arteries whichsupplying blood to the heart. Often thesedeposits can harden and form plaques. Plaques are at risk of rupture, Due to thisundersurface of the artery lining is exposed, provoking an injury response.
Inthis instance the blood flow through the artery can be blocked by the clotformation. By this starving of muscle occurs due to no supply of oxygen toheart muscles then heart attack occurs. Because of this atherosclerosis processdescribed above, is predominantly a silent process with no symptoms. Althoughtreatment for heart attacks has improved greatly over the years, a third ofheart attack patients still die within 28 days, with the majority of thesedeaths occurring in the first 24 hours.Statins has two main mechanisms of action. First they stabilise plaques, by making them lesslikely to rupture and therefore reducing the heart attacks.
Second, they reducethe levels of cholesterol in the blood by inhibiting the enzyme in theliver that produces it. So less cholesterol level in the blood stream meansthat there will be less deposition of plaques in walls of the artery. There aretwo types of cholesterol: HDL,is the “good”, cholesterol type; and LDL, the “bad”cholesterol type or disease-causing type. Cholesterol is measured in unitscalled mmol/L, and a large meta-analysis was conducted in 20121 and concluded that for every 1 mmol/Ldrop in LDL (the “bad”) cholesterol, there was a reduction of 24% in the riskof heart attack, 15% in the risk of stroke, and 19% in the risk of deathfrom coronary artery disease.
The average patient on an appropriate statinat the correct dose might therefore expect their future cardiovascularrisk to be halved.