drugs are used to lower cholesterol in the body, actually body needs some
cholesterol to work. If cholesterol level increases in blood it stick to the
walls of arteries and makes narrow or even block them.
diet and exercise if cholesterol levelsdid not reduce, then it will be necessary
to take medicine. Often, this medicine is a statin. Statins they lower LDL(bad)
cholesterol levels and raise HDL (good) cholesterol levels. This will
make slow the formation of plaques in arteries.
are safe for most people. But these medicines are not recommended for pregnant
patients and patients with chronic liver disease. They can also cause serious
muscle problems. Some statins interact adversely with other drugs. This may cause
fewer side effects.
Statins – the good,
the bad and the controversy
Statins – the good
If cholesterol levels are high in the body it causes coronary
artery disease due to this fatty deposits build up in the walls of arteries which
supplying blood to the heart. Often these
deposits can harden and form plaques. Plaques are at risk of rupture, Due to this
undersurface of the artery lining is exposed, provoking an injury response. In
this instance the blood flow through the artery can be blocked by the clot
formation. By this starving of muscle occurs due to no supply of oxygen to
heart muscles then heart attack occurs. Because of this atherosclerosis process
described above, is predominantly a silent process with no symptoms. Although
treatment for heart attacks has improved greatly over the years, a third of
heart attack patients still die within 28 days, with the majority of these
deaths occurring in the first 24 hours.
Statins has two main mechanisms of action. First they stabilise plaques, by making them less
likely to rupture and therefore reducing the heart attacks. Second, they reduce
the levels of cholesterol in the blood by inhibiting the enzyme in the
liver that produces it. So less cholesterol level in the blood stream means
that there will be less deposition of plaques in walls of the artery. There are
two types of cholesterol: HDL,is the “good”, cholesterol type; and LDL, the “bad
“cholesterol type or disease-causing type. Cholesterol is measured in units
called mmol/L, and a large meta-analysis
was conducted in 20121 and concluded that for every 1 mmol/L
drop in LDL (the “bad”) cholesterol, there was a reduction of 24% in the risk
of heart attack, 15% in the risk of stroke, and 19% in the risk of death
from coronary artery disease. The average patient on an appropriate statin
at the correct dose might therefore expect their future cardiovascular
risk to be halved.