Diabetes


Nearly 16 million people in the United States–nearly one out of every 17 people–have diabetes. And about 1,800 new cases are diagnosed each day.
Technically, this disease is known as “diabetes mellitus,” diabetes from the Greek for excessive urination, a symptom the ancients noticed, and mellitus, from the Latin for honey–diabetic urine is filled with sugar and is sweet.

There are three types of diabetes: type 1, type 2, and gestational diabetes. All of them are a little different. But everyone with diabetes has one thing in common: Little or no ability to move sugar–or glucose–out of their blood into their cells, where it is the body’s primary fuel.
Everyone has glucose in their blood, whether or not they have diabetes. This glucose comes from food. When we eat, the digestive process breaks down carbohydrates into glucose, which is absorbed into the blood in the small intestine.
People who don’t have diabetes rely on insulin, a hormone made in the pancreas, to move glucose from the blood into the body’s billions of cells. But people who have diabetes either don’t produce insulin or can’t efficiently use the insulin they produce. Without insulin, they can’t move glucose into the cells. Glucose accumulates in the blood, a condition called hyperglycemia (“hyper” = too much, “glycemia” = glucose in the blood). Hyperglycemia causes intense thirst, the need to urinate frequently, blurred vision, fatigue, and other symptoms. Over time, high blood glucose can cause very serious medical problems.
Adding up the total toll of diabetes complications, the disease is one of the nation’s leading causes of death. All diabetes complications can be largely prevented by practicing what is known as “tight control,” keeping your blood glucose level as close to normal as possible. This takes time and energy, but many diabetics do it successfully and live full lives without much trouble.
Scientists don’t know exactly what causes diabetes, but it appears to result from a combination of genetics and environmental factors, including viral infections, poor diet, and sedentary lifestyle.
Currently, there is no cure for diabetes, but the good news is that the disease can be managed. People with diabetes can live rich, happy lives.
Type 1 and type 2 diabetes have different causes. Yet two factors are important in both. First, you must inherit a predisposition to the disease. Second, something in your environment must trigger diabetes. Genes alone are not enough. One proof of this is identical twins. Identical twins have identical genes. Yet when one twin has type 1 diabetes, the other gets the disease at most only half the time. When one twin has type 2 diabetes, the other’s risk is at most 3 in 4. In most cases of type 1 diabetes, people need to inherit risk factors from both parents. Scientists think these factors must be more common in whites because whites have the highest rate of type 1 diabetes. Because most people who are at risk do not get diabetes, researchers want to find out what the environmental triggers are.
One trigger might be related to cold weather. Type 1 diabetes develops more often in winter than summer and is more common in places with cold climates. Another trigger might be viruses. Perhaps a virus that has only mild effects on most people triggers type 1 diabetes in others.

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Early diet may also play a role. Type 1 diabetes is less common in people who were breastfed and in those who first ate solid foods at later ages. In many people, the development of type 1 diabetes seems to take many years. In experiments that followed relatives of people with type 1 diabetes, researchers found that most of those who later got diabetes had certain autoantibodies in their blood for years before. (Antibodies are proteins that destroy bacteria or viruses. Autoantibodies are antibodies ‘gone bad,’ which attack the body’s own tissues.)
Type 2 diabetes has a stronger genetic basis than type 1, yet it also depends more on environmental factors. Sound confusing? What happens is that a family history of type 2 diabetes is one of the strongest risk factors for getting the disease but it only seems to matter in people living a Western lifestyle.
Americans and Europeans eat too much fat and too little carbohydrate and fiber, and they get too little exercise. Type 2 diabetes is common in people with these habits. The ethnic groups in the United States with the highest risk are blacks, Mexican Americans, and Pima Indians. In contrast, people who live in areas that have not become Westernized tend not to get type 2 diabetes, no matter how high their genetic risk. Obesity is a strong risk factor for type 2 diabetes. Obesity is most risky for young people and for people who have been obese for a long time. Gestational diabetes is more of a puzzle. Women who get diabetes while they are pregnant are more likely to have a family history of diabetes, especially on their mothers’ side. But as in other forms of diabetes, nongenetic factors play a role. Older mothers and overweight women are more likely to get gestational diabetes.
In general, if you are a man with type 1 diabetes, the odds of your child getting diabetes are 1 in 17. If you are a woman with type 1 diabetes and your child was born before you were 25, your child’s risk is 1 in 25; if your child was born after you turned 25, your child’s risk is 1 in 100. Your child’s risk is doubled if you developed diabetes before age 11. If both you and your partner have type 1 diabetes, the risk is between 1 in 10 and 1 in 4. There is an exception to these numbers. About 1 in every 7 people with type 1 diabetes has a condition called type 2 polyglandular autoimmune syndrome. In addition to having diabetes, these people also have thyroid disease and a poorly working adrenal gland. Some also have other immune system disorders. If you have this syndrome, your child’s risk of getting the syndrome including type 1 diabetes is 1 in 2.
Researchers are learning how to predict a person’s odds of getting diabetes. For example, most whites with type 1 diabetes have genes called HLA-DR3 or HLA-DR4. If you and your child are white and share these genes, your child’s risk is higher. (Suspect genes in other ethnic groups are less well studied. The HLA-DR7 gene may put blacks at risk, and the HLA-DR9 gene may put Japanese at risk.)
Other tests can also make your child’s risk clearer. A special test that tells how the body responds to glucose can tell which school-aged children are most at risk. Another more expensive test can be done for children who have siblings with type 1 diabetes. This test measures antibodies to insulin, to islet cells in the pancreas, or to an enzyme called glutamic acid decarboxylase. High levels can indicate that a child has a higher risk of developing type 1 diabetes.

Type 2 diabetes runs in families. In part, this tendency is due to children learning bad habits eating a poor diet, not exercising–from their parents. But there is also a genetic basis. In general, if you have type 2 diabetes, the risk of your child getting diabetes is 1 in 7 if you were diagnosed before age 50 and 1 in 13 if you were diagnosed after age 50. Some scientists believe that a child’s risk is greater when the parent with type 2 diabetes is the mother. If both you and your partner have type 2 diabetes, your child’s risk is about 1 in 2. People with certain rare types of type 2 diabetes have different risks. If you have the rare form called maturity-onset diabetes of the young (MODY), your child has almost a 1-in-2 chance of getting it, too.


Bibliography
Latest Diabetes News and Information. NetHealth Inc. 1998 .


American Diabetes Association. American Diabetes Association. 1998 .


Diabetes Mellitus Microsoft Encarta 96 Encyclopidia. Vers. 96. 1993-1995.

Diabetes


Alicia Purdom
Class: English 101
Professor: Mrs. Kravitz-Sheppard
Date: February 5,2004
Diabetes (diabetes mellitus)
Diabetes is a disease characterized by excessive urination. Diabetes mellitus is caused by insufficient insulin production or lack of responsiveness to insulin, resulting in hyperglycemia (high blood glucose levels). There are 2 primary types of diabetes mellitus, type I (insulin-dependent or juvenile-onset), which may be caused by an autoimmune response, and type II (non-insulin-dependent or adult-onset). Diabetes insipidus is typically due to hormonal dysregulation.

Diabetes mellitus (DM) is a chronic metabolic disorder caused by an absolute or relative deficiency of insulin, an anabolic hormone. Insulin is produced in the pancreas by the beta cells of the islets of Langerhans. Absence, destruction, or loss of these cells causes an absolute deficiency of insulin, leading to type 1 diabetes (insulin-dependent diabetes mellitus IDDM). Most children with diabetes have IDDM and a lifetime dependence on exogenous insulin.
Type 2 diabetes (non-insulin-dependent diabetes mellitus NIDDM) is a heterogeneous disorder. Patients with NIDDM have insulin resistance, and their beta cells lack the ability to overcome this resistance. Although this form of diabetes previously was uncommon in children, 20% or more of new patients with diabetes in childhood and adolescence now have NIDDM, a change associated with increased rates of obesity.
Insulin is essential to process carbohydrate, fat, and protein. Insulin reduces blood glucose levels by allowing glucose to enter muscle cells and fat cells and by stimulating the conversion of glucose to glycogen as a carbohydrate store. Insulin also inhibits the release of stored glucose from liver glycogen and slows the breakdown of fat to triglycerides, free fatty acids, and ketones. Additionally, insulin slows the breakdown of protein for glucose production.
Hyperglycemia results when insulin deficiency leads to uninhibited gluconeogenesis and prevents the use and storage of circulating glucose. The kidneys cannot reabsorb the excess glucose load, causing glycosuria, osmotic diuresis, thirst, and dehydration. Increased fat and protein breakdown leads to ketone production and weight loss. Without insulin, a child with IDDM wastes away and eventually dies from diabetic ketoacidosis.

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Information on mortality rates is difficult to ascertain without complete national registers of childhood diabetes, although age-specific mortality probably is double that of the general population. Particularly at risk are children aged 1-4 years who may die with DKA at the time of diagnosis. Adolescents also are a high-risk group. Most deaths result from delayed diagnosis or neglected treatment and subsequent cerebral edema during treatment for DKA, although untreated hypoglycemia also causes some deaths.
IDDM complications are comprised of 3 major categories: acute complications, long-term complications, and complications caused by associated autoimmune diseases. Acute complications reflect the difficulties of maintaining a balance between insulin therapy, dietary intake, and exercise. Acute complications include hypoglycemia, hyperglycemia, and DKA. Long-term complications arise from the damaging effects of prolonged hyperglycemia and other metabolic consequences of insulin deficiency on various tissues. While long-term complications are rare in childhood, maintaining good control of diabetes is important to prevent complications from developing in later life. The likelihood of developing complications appears to depend on the interaction of factors such as metabolic control, genetic susceptibility, lifestyle, pubertal status, and gender. Most cases of IDDM are the result of environmental factors interacting with a genetically susceptible person. This interaction leads to the development of autoimmune disease directed at the insulin-producing cells of the pancreatic islets of Langerhans. These cells are progressively destroyed, with insulin deficiency usually developing after the destruction of 90% of islet cells.

Diabetes is a disease that can be deadly if not treated correctly. Most people with diabetes have one of the two types and can be treated with pills or insulin shots. My mother has type II diabetes, and helping her cope with her disease gives me a wider outlook on it. I see her give herself shots every day to monitor her blood sugar levels; and I also see her taking medicine to help control the amount of glucose to be present in her system. Hopefully one day there will be a cure for this disease so that many people ,along with my mother, can live lives without pain and be healthy.


Resources:
Diabetes Mellitus: William H Lamb, MD, FRCP, FRCPCH
Hypoglycemia for Dummies by Cheryl Chow
American diabetes association complete guide to diabetes by American

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